Oral Immunization against Tetanus, using Liposome-Entrapped Tetanus Toxoid

Immunization with Tetanus Toxoid

Although immunization with tetanus toxoid cannot be expected to produce an adequate permanent immunity, a number of investigators have confirmed and extended the observation of Ramon3 to the effect that an organism, once immunized, will respond to further injections of toxoid with an accelerated and increased antitoxin production. That this response to the "injection de rappel" does occur has b...

Tetanus toxoid immunization to reduce mortality from neonatal tetanus

BACKGROUND Neonatal tetanus remains an important and preventable cause of neonatal mortality globally. Large reductions in neonatal tetanus deaths have been reported following major increases in the coverage of tetanus toxoid immunization, yet the level of evidence for the mortality effect of tetanus toxoid immunization is surprisingly weak with only two trials considered in a Cochrane review. ...

Oral Immunization against Diphtheria and Tetanus Infections by Fluid Dphtheria and Tetanus Toxoids

Immunization against Tetanus.

IN A RECENT preliminary communication (Smith, Evans, Jones, Gear, Cunliffe and Barr, 1963) the results of a clinical trial of adsorbed tetanus toxoid were presented. This demonstrated the efficacy and safety of simultaneous injections of adsorbed toxoid and tetanus antitoxin. Casualty officers and general practitioners are frequently faced with the problem of immunization against tetanus and ar...

Severe tetanus--in spite of tetanus toxoid.

A 66-year-old man sustained an injury to his right foot while gardening. Despite receiving tetanus toxoid one hour later and adequate wound toilet, he developed severe tetanus complicated with autonomic dysfunction six days later. He died 20 days after admission. This case shows that tetanus toxoid alone may not be sufficient to prevent tetanus in wounded patients. Careful consideration must be...